Frame Module
Automated Cleaning to avoid cross contaminations
The Clean & Rinse module is embedded in the Frame of SMILLA and enables automated cleaning and rinsing of the sample port, tubing and the flow cell after each measurement. The convenient backflush option removes clogging particles without the need to remove the flow cell.
The frame is equipped with multiple sensors to ensure the reliable operation of SMILLA, in stand-alone mode as well as in combination with the liquid-handling system.
The special design of the frame allows modularity and flexible configurations of the HiRes-FIM, LO and pump modules.
Depending on the application, different flow setups are possible:
Top-Down-Configuration
In top-to-bottom configuration, the sample is introduced to the sample port at the top of the instrument and transported by the pump module through the HiRes-FIM/LO-module to the waste bottle at the bottom of the instrument. It is recommended for all applications with sample volumes of up to approximately 5ml. For the top-to-bottom configuration, automated cleaning including monitoring of background contamination is included.
Bottom-to-Top-Modus
In the bottom-to-top mode, the sample is placed within a beaker on a raiseable stage at the bottom of the instrument. The sample will be transported by the pump module through HiRes-FIM/LO module to the waste bottles at the side of the frame. This configuration is recommended for all applications with large sample volumes and/or samples with quickly sedimenting particles. The raisable stage is also equipped with a magnetic stirrer to provide sample homogenization. For the bottom-to-top configuration, manual cleaning is required.
All modules
HiRes-FIM module
for high-resolution flow imaging microscopy
LO module
for precise, orthogonal light obscuration analysis
Pump module
for a steady and fast sample transport, adaptable to your type of sample and sample volume
Frame module
with the implemented Clean & Rinse system, enabling automated and thorough system cleaning between measurements – ideal for high throughput environments